Diagnosis of oral pigmentations and malignant transformations ScienceDirect a Melanotic macule at the wetdry line of the lower lip. b Melanotic Download Scientific Diagram Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Figure 1 from Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule Semantic Scholar Pigmented Lesions and Melanoma Plastic Surgery KeyPlastic Surgery Key Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.